From WCG website
Outsmart Ebola Together Approaches Completion of Initial Phase
By: Dr. Hal Wasserman
The Scripps Research Institute
26 Jan 2017
Summary
The Outsmart Ebola Together research team has conducted an enormous number of virtual docking experiments, and they are now ready to embark on a new stage of their research.
The Ebola virus killed many thousands of people in 2014 during the largest outbreak of the disease since it was first discovered in 1976. Significantly, research has shown that the virus's long incubation period and our highly connected modern world could allow the virus to spread to new geographies and across oceans. Currently, there are no approved treatments or vaccines for this deadly disease, and the search for an effective antiviral drug to treat the disease is a high priority.
Outsmart Ebola Together is now approaching completion of its first phase, having conducted hundreds of thousands of docking computations. In this phase, we have simulated the binding of potential small-molecule drugs against atomic structures of proteins of the filovirus family. We have in particular targeted the receptor binding site (RBS) of the Ebola virus glycoprotein (GP), which plays a key role in viral entry into human cells.
For Ebola to infect a human cell, the RBS must bind to a receptor in the cell membrane, thereby infiltrating the GP into one of the inner cellular compartments, known as the endosome. Once inside the endosome, the presence of enzymes and an acidic environment transform the molecular structure of GP, allowing it to fuse with the endosome wall and so gain entry to the cytoplasm.
Our study now expands to consider multiple stages in the dynamic molecular transformations of GP and other Ebola proteins. These transformations are essential to the viral life cycle, and therefore represent an ideal target for the design of effective antiviral drugs.
Thank you to all volunteers who have supported this project.
Outsmart Ebola Together Approaches Completion of Initial Phase
Forum rules
Welcome to The Scottish Boinc Team boards. See forum rules in pinned post. If you can't be bothered then try not to be too naughty as I have a delete button to press and a ban hammer to swing.
Welcome to The Scottish Boinc Team boards. See forum rules in pinned post. If you can't be bothered then try not to be too naughty as I have a delete button to press and a ban hammer to swing.
Jump to
- Guest Access Forum
- General
- ↳ Fun and Games
- ↳ General
- ↳ Newshound RSS feeds
- ↳ Welcome
- ↳ Sneak Peak - Yearly Team Individual Stats Competition
- Competitions and Kudos
- ↳ Badges? We don't need no stinkin' badges!
- ↳ Kudos
- ↳ Milestones
- ↳ Milestones Archives
- ↳ Throw down the Gauntlet
- ↳ Pending Competitions
- ↳ archive
- ↳ TSBT Competitions
- Home Port of Anguillan Pirates
- ↳ Anguillan Pirates
- ↳ Pirates on Tour
- Hardware
- ↳ ASIC & FPGA Enchanced Devices
- ↳ Benchmarking and Hardware
- ↳ Graphics Processing Unit (GPU)
- ↳ Single-board Computers
- Operating Systems & Software
- ↳ Android
- ↳ BOINC Software Applications
- ↳ Linux
- ↳ Mac OS
- ↳ Microsoft Windows
- ↳ BOINC Technical Conventions and Papers
- ↳ FreeBSD
- BOINC Projects
- ↳ Biology / Medical
- ↳ GPUgrid
- ↳ RNA World
- ↳ Rosetta
- ↳ SiDock
- ↳ TN-Grid
- ↳ CERN
- ↳ LHC
- ↳ ATLAS
- ↳ Beauty
- ↳ CSM
- ↳ vLHC
- ↳ Chemistry
- ↳ QuChemPedIA
- ↳ Earth Sciences
- ↳ Climate Prediction
- ↳ Quake Catcher
- ↳ Mathematics / Computing
- ↳ Amicable Numbers
- ↳ Collatz Conjecture
- ↳ Gerasim
- ↳ GPUGRID
- ↳ iTHENA
- ↳ Loda
- ↳ NFS
- ↳ NumberFields
- ↳ ODLK
- ↳ ODLK1
- ↳ PGFNS
- ↳ PrimeGrid
- ↳ RakeSearch
- ↳ SRBase
- ↳ T.Brada
- ↳ ramanujan
- ↳ Van Der Waerden Numbers
- ↳ Wanless
- ↳ YAFU
- ↳ Physics
- ↳ nanoHub
- ↳ RADIOACTIVE
- ↳ Social Sciences
- ↳ MindModeling
- ↳ Space Sciences
- ↳ Asteroids
- ↳ Cosmology
- ↳ Einstein
- ↳ Gaia@home
- ↳ MilkyWay
- ↳ Universe
- ↳ Umbrella projects
- ↳ BOINC@TACC
- ↳ Citizen Science Grid
- ↳ Wildlife@Home
- ↳ DNA@Home
- ↳ SubsetSum@Home
- ↳ Moo! Wrapper
- ↳ yoyo
- ↳ World Community Grid
- ↳ General Posts
- ↳ Africa Rainfall Project
- ↳ Fight AIDS
- ↳ Help Cure Muscular Dystrophy
- ↳ Help Stop TB
- ↳ Mapping Cancer Markers
- ↳ Microbiome Immunity Project
- ↳ OpenPandemics - COVID-19
- ↳ Open Zika
- ↳ Outsmarting Ebola
- ↳ Smash Childhood Cancer
- ↳ Retired Projects
- ↳ Brainstorm
- ↳ Miscellaneous
- ↳ WUProp
- ↳ Permanent Testing
- ↳ Albert
- ↳ BURP
- ↳ RALPH
- ↳ Retired Projects
- ↳ ABC@home
- ↳ ABC Lattices
- ↳ Acoustics
- ↳ AlmereGrid Boinc Grid
- ↳ AlmereGrid TestGrid
- ↳ AndersonAttack@home
- ↳ Beal@Home
- ↳ Bitcoin Utopia
- ↳ CAS
- ↳ Chess960@Home
- ↳ Constellation
- ↳ CONVECTOR
- ↳ Correlizer
- ↳ Climate@Home
- ↳ Climateprediction.net Beta
- ↳ DBN UPPER BOUND
- ↳ DENIS
- ↳ DistrRTgen
- ↳ DHEP
- ↳ DistributedDataMining
- ↳ DrugDiscovery@Home
- ↳ DrugDiscovery
- ↳ Docking@Home
- ↳ Duchamp
- ↳ EDGeS@Home
- ↳ Enigma
- ↳ eOn
- ↳ FiND@Home
- ↳ iGEM@Home
- ↳ Goofyxgrid
- ↳ Gridcoin Finance
- ↳ ibercivis
- ↳ Ideologias@Home
- ↳ Kryptos@Home
- ↳ Lattices @Home
- ↳ Leiden Classical
- ↳ Malaria Control
- ↳ Najmanovich Research Group
- ↳ Nanosurface@home
- ↳ Neurona@Home
- ↳ OProject@Home
- ↳ OPTIMA@HOME
- ↳ Physics
- ↳ Pirates@Home
- ↳ Plagiarism@Home
- ↳ POEM@HOME
- ↳ Primaboinca
- ↳ QMC@Home
- ↳ Rioja Science
- ↳ Renderfarm.fi
- ↳ SAT@home
- ↳ SETI
- ↳ SETI Beta
- ↳ SimOne@home
- ↳ SIMAP Production
- ↳ SLinCA
- ↳ Spatiotemporal Quality of Service (QoS)
- ↳ Stop@home
- ↳ Superlink@Technion
- ↳ SZTAKI
- ↳ The Lattice Project
- ↳ theSkyNet POGS
- ↳ VGTU
- ↳ Virtual Prairie
- ↳ Volpex
- ↳ XANSONS for COD
- ↳ Non-BOINC Projects
- Links and Help Section
- ↳ Links
- ↳ Help
- ↳ Website Problems